[article] 
inMolecular psychiatry > 24 (22 juin 2018) . - p. 88-107

Titre :	The ASD living biology : from cell proliferation to clinical phenotype
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Eric COURCHESNE, Auteur ; Tiziano PRAMPARO, Auteur ; Vahid H. GAZESTANI, Auteur ; Michael V. LOMBARDO, Auteur ; Karen PIERCE, Auteur
Année de publication :	2018
Article en page(s) :	p. 88-107
Langues :	Anglais (eng)
Concepts :	[Thesaurus DOCautisme] Trouble du spectre de l'autisme [Thesaurus DOCautisme] Cellule reproductrice [Thesaurus DOCautisme] Phénotype [Thesaurus DOCautisme] Recherche biomédicale [Thesaurus DOCautisme] Génétique
Index. décimale :	AUT.21 Etiologie biomédicale
Résumé :	Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the lay public because of its uncertain origins and striking and unexplained clinical heterogeneity. Here we review genetic, genomic, cellular, postmortem, animal model, and cell model evidence that shows ASD begins in the womb. This evidence leads to a new theory that ASD is a multistage, progressive disorder of brain development, spanning nearly all of prenatal life. ASD can begin as early as the 1st and 2nd trimester with disruption of cell proliferation and differentiation. It continues with disruption of neural migration, laminar disorganization, altered neuron maturation and neurite outgrowth, disruption of synaptogenesis and reduced neural network functioning. [résumé d'auteur]
Sous-type :	Article
En ligne :	https://www.nature.com/articles/s41380-018-0056-y
Permalink :	https://cra-paysdelaloire.centredoc.fr/index.php?lvl=notice_display&id=10159

[article] The ASD living biology : from cell proliferation to clinical phenotype [Texte imprimé et/ou numérique] / Eric COURCHESNE, Auteur ; Tiziano PRAMPARO, Auteur ; Vahid H. GAZESTANI, Auteur ; Michael V. LOMBARDO, Auteur ; Karen PIERCE, Auteur . - 2018 . - p. 88-107.
Langues : Anglais (eng)
in Molecular psychiatry > 24 (22 juin 2018) . - p. 88-107

Concepts :	[Thesaurus DOCautisme] Trouble du spectre de l'autisme [Thesaurus DOCautisme] Cellule reproductrice [Thesaurus DOCautisme] Phénotype [Thesaurus DOCautisme] Recherche biomédicale [Thesaurus DOCautisme] Génétique
Index. décimale :	AUT.21 Etiologie biomédicale
Résumé :	Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the lay public because of its uncertain origins and striking and unexplained clinical heterogeneity. Here we review genetic, genomic, cellular, postmortem, animal model, and cell model evidence that shows ASD begins in the womb. This evidence leads to a new theory that ASD is a multistage, progressive disorder of brain development, spanning nearly all of prenatal life. ASD can begin as early as the 1st and 2nd trimester with disruption of cell proliferation and differentiation. It continues with disruption of neural migration, laminar disorganization, altered neuron maturation and neurite outgrowth, disruption of synaptogenesis and reduced neural network functioning. [résumé d'auteur]
Sous-type :	Article
En ligne :	https://www.nature.com/articles/s41380-018-0056-y
Permalink :	https://cra-paysdelaloire.centredoc.fr/index.php?lvl=notice_display&id=10159